Gq-mER signaling has opposite effects on hypothalamic orexigenic and anorexigenic neurons
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Nicotine excites hypothalamic arcuate anorexigenic proopiomelanocortin neurons and orexigenic neuropeptide Y neurons: similarities and differences.
Two of the biggest health problems facing us today are addiction to nicotine and the increased prevalence of obesity. Interestingly, nicotine attenuates obesity, but the underlying mechanism is not clear. Here we address the hypothesis that if weight-reducing actions of nicotine are mediated by anorexigenic proopiomelanocortin (POMC) neurons of the hypothalamic arcuate nucleus, nicotine should ...
متن کاملNicotine excites hypothalamic arcuate anorexigenic 3 proopiomelanocortin neurons and orexigenic neuropeptide Y 4 neurons : similarities and differences 5 6
24 Two of the biggest health problems facing us today are addiction to nicotine, and 25 the increased prevalence of obesity. Interestingly, nicotine attenuates obesity, but the 26 underlying mechanism is not clear. Here we address the hypothesis that if weight27 reducing actions of nicotine are mediated by anorexigenic POMC neurons of the 28 hypothalamic arcuate nucleus, nicotine should excite ...
متن کاملPeptide YY(3-36) inhibits both anorexigenic proopiomelanocortin and orexigenic neuropeptide Y neurons: implications for hypothalamic regulation of energy homeostasis.
Peptide YY(3-36) (PYY(3-36)) is released by endocrine cells of the gut and may serve as an important long-distance neuropeptide signal relating energy balance information to the brain to depress food intake. The postulated mechanism is the activation of anorexigenic proopiomelanocortin (POMC) neurons of the hypothalamic arcuate nucleus. In striking contrast, using voltage and current-clamp reco...
متن کاملInhibition of hypothalamic MCT1 expression increases food intake and alters orexigenic and anorexigenic neuropeptide expression
Hypothalamic glucosensing, which involves the detection of glucose concentration changes by brain cells and subsequent release of orexigenic or anorexigenic neuropeptides, is a crucial process that regulates feeding behavior. Arcuate nucleus (AN) neurons are classically thought to be responsible for hypothalamic glucosensing through a direct sensing mechanism; however, recent data has shown a m...
متن کاملMCT2 Expression and Lactate Influx in Anorexigenic and Orexigenic Neurons of the Arcuate Nucleus
Hypothalamic neurons of the arcuate nucleus control food intake, releasing orexigenic and anorexigenic neuropeptides in response to changes in glucose concentration. Several studies have suggested that the glucosensing mechanism is governed by a metabolic interaction between neurons and glial cells via lactate flux through monocarboxylate transporters (MCTs). Hypothalamic glial cells (tanycytes...
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ژورنال
عنوان ژورنال: Steroids
سال: 2014
ISSN: 0039-128X
DOI: 10.1016/j.steroids.2013.11.007